Even though the eczematous response is perhaps the single most uniquely dermatologic form of reaction, only a limited amount of information is available with respect to its evolution and almost nothing is known about the histochemical changes which occur in its various phases. The reasons for this inadequate information are not a lack of interest or enthusiasm on the part of the dermatologists but rather practical difficulties which often hamper investigations in this field. In order to study the evolution of the eczematous response, i. e., the reaction characterized by intra- and intercellular edema, spongiosis, and intra-epidermal vesiculation in all its details, it becomes necessary to examine sections from the same skin area at close intervals. Only in such a way is it possible to gain that insight into the sequence of histopathologic events, the sum total of which might furnish a dynamic rather
BAER RL, ROSENTHAL SA, SIMS CF, Hagel B, Kaplan G. The Allergic Eczema-like Reaction and the Primary Irritant Reaction: A Histologic Comparison of Their Evolution in the Acanthotic Skin of Guinea Pigs. AMA Arch Derm. 1957;76(5):549–560. doi:10.1001/archderm.1957.01550230013003
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