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December 1957

Fungous Infections of the Skin Treated with Pyrrobutamine Compounds

Author Affiliations


From the Dermatological Clinics of the Cincinnati Health Department and the Laboratory of Mycology of the Department of Dermatology, University of Cincinnati College of Medicine.

AMA Arch Derm. 1957;76(6):783-787. doi:10.1001/archderm.1957.01550240101022

The in vitro fungistatic activity of certain antihistamine drugs has been previously recorded. Apparently there is considerable variation among different members of this group of agents in this regard. Some are altogether incapable of inhibiting fungi, whereas others possess this characteristic in varying degree. Carson and Campbell1 demonstrated the in vitro fungistatic activity against several species of pathogenic fungi (Trichophyton mentagrophytes, Trichophyton rubrum, Trichophyton ferrugineum, Microsporum gypseum, Microsporum canis and Epidermophyton floccosum) of diphenylpyraline, antazoline (Antistine), and tripelennamine (Pyribenzamine). Concentrations as low as 0.1 mg/ml. were capable of restricting the growth of some of the organisms, but higher levels of more than 1 mg/ml. were required for complete suppression of certain fungi. Carson and Campbell found that the fungistatic effect of the drugs tested could be reduced or abolished in media adjusted to pH 5 and that for tripelennamine there was an