A 33-year-old white woman in her sixth month of pregnancy was seen by us for the first time in May, 1954. She reported that she had had a lesion on the left side of her face for five weeks, which had been treated with one intramuscular injection of penicillin and with topical applications of an ointment containing a combination of neomycin and bacitracin (Neobacin). At the time of our first examination, on May 18, 1954, there was a moist, red, granulomatous lesion, about 2 cm. in diameter, involving the skin in the vicinity of the left zygoma. Several small pustules were scattered about the periphery of this lesion. Midway between the cutaneous lesion and the left ear was a slightly tender regional lymph node, about 0.5 cm. in diameter. There were also two or three small, palpable but nontender lymph nodes in the left anterior cervical chain. The