The subject of keratoacanthoma has been extensively covered in recent reports by Binkley and Johnson1; Ereaux, Schopflocher, and Fournier,2 and Epstein, Biskind, and Pollack.3 These authors adequately reviewed the classification and development of these lesions from the earliest reports of verrucome by Gougerot in 1917 to the present-day conception of keratoacanthoma. They came to the conclusion that the verrucome and the molluscum sebaceum are the solitary form of keratoacanthoma, while the lesions described as self-healing epithelioma (Ferguson Smith) and the tumor-like keratosis of Poth are the multiple form of the same disease.
While both types are histologically keraacanthoma, there is very little similarity in the clinical appearance. The solitary acanthoma is common, while the multiple form is very rare. An extensive and careful survey by Rook and Moffatt4 on this subject in 1956 shows that only 23 cases
EPHRAIM AJ, KAUFMAN JJ. Multiple Keratoacanthoma: Report of an Extensive Case and Its Response to Therapy. AMA Arch Derm. 1958;77(2):191–194. doi:10.1001/archderm.1958.01560020043004
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