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April 1958


AMA Arch Derm. 1958;77(4):454-472. doi:10.1001/archderm.1958.01560040078018

Treatment of Chronic Lupus Erythematosus: Effectiveness of Plaquenil and APA (Aralen 65 mg., Plaquenil 50 mg., Atabrine 25 mg.) as Compared with Aralen, with Observations on Side-Reactions and Toxicity; Report and Presentation of Unusual Cases. Presented by Drs. M. J. Tye, H. B. Ansell, M. Wolf, B. Appel, and B. Schiff.

Our experience with Aralen (chloroquine phosphate) has been reported (New England J. Med. 251:252-255 [July 8] 1954).

Plaquenil: (a) It is our impression that Plaquenil possesses some effectiveness in the treatment of chronic lupus erythematosus but that it does not give quite as rapid or as good a response as Aralen.

(b) Disturbances of visual accommodation and nausea and vomiting, which occasionally develop with Aralen therapy, did not occur in the same patients subsequently given Plaquenil. It would therefore appear that Plaquenil may be given to those who cannot tolerate Aralen.

APA: (a) In general, the response

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