Melanoderma associated with asthma was reported by Herraiz1 in 1945. He stated that several patients had previously mentioned darkening of the skin accompanying asthmatic attacks and was able to verify this phenomenon in two personally observed females in Argentina. We have been able to observe a further similar case at intervals for over two years.
Report of Case
The patient was a 64-year-old widow.
Race.—In veiw of the mixed nature of the population of the Union of South Africa, this was carefully assessed. Her maternal grandparents were Portuguese; the others, Afrikaans. Afrikaans South Africans are whites of mixed Dutch and Huguenot French descent; miscegenation with the indigenous population cannot be excluded but would be so far removed in time as to be of little importance. She was always an olive-complexioned brunette, and we have seen a wedding photograph from 1914 in which her coloring was lighter than
LOEWENTHAL LJA, SHAPIRO S. Asthma Melanodermica: Report of a Third Case, with Investigations. AMA Arch Derm. 1958;78(2):210–213. doi:10.1001/archderm.1958.01560080070013
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