Dermatitis of the eyelids, face, and neck due to sensitivity to an ingredient in nail lacquer, chiefly the formaldehyde-sulfonamide resin used as a means of imparting luster to the lacquer film,1,2 is well known. During the past year I have seen four patients with a patchy eczematous contact-type dermatitis of the eyelids, face, chin, and neck who gave negative results with patch tests with ordinary nail lacquer but positive results with patch tests with pearly or frosted nail lacquer.
Patch tests with the various ingredients in the nail lacquer, including the solvent, plasticizer, resin, and pigment, were negative, but patch tests to the pearly material were positive. The pearly material is made from the fish scales of sardines and consists chiefly of guanine. Patch tests with pure powdered guanine and powdered defatted sardine fish scales were positive in all 4 patients and negative in 20 controls. Patch tests with pure powdered guanine were positive
STRITZLER C. Dermatitis of the Face Caused by Guanine in Pearly Nail Lacquer. AMA Arch Derm. 1958;78(2):252–253. doi:10.1001/archderm.1958.01560080112021
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