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September 1958

Granuloma Pyogenicum: Differential Diagnosis

Author Affiliations

Los Angeles

AMA Arch Derm. 1958;78(3):341-347. doi:10.1001/archderm.1958.01560090055013

Granuloma pyogenicum is a term introduced by Hartzell,1 in 1904, to describe a benign human tumor occurring on skin and mucous membranes.

The etiology of this tumor is not fully established, though trauma and infection with pyogenic bacteria are frequently associated. Michelson2 reported a history of preceding trauma in 50% of the cases in his series, and Crocker3 defined granuloma pyogenicum as "a fungating tumor produced by pus cocci."

These lesions are well described in the literature.4 They occur at all ages and equally distributed between the sexes. The preferred sites are hands, feet, lips, face, upper part of trunk, and umbilical regions on the skin and the buccal, nasal, laryngeal, vaginal, and cervical mucosae. During gestation, they occur on oral mucosa frequently enough to have been given the special title of pregnancy tumor.5

They present as vascular tumors, bright red

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