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November 1958

Subcorneal Pustular Dermatosis: Report of a Case

Author Affiliations


From the Departments of Dermatology of Wayne State University and Receiving Hospital (Dr. Hermann Pinkus, Acting Chairman). Fellow in Dermatology, Wayne State University College of Medicine.

AMA Arch Derm. 1958;78(5):589-591. doi:10.1001/archderm.1958.01560110035004

In a recent paper, Sneddon and Wilkinson1 described cases of a chronic vesiculopustular eruption which was characterized histologically by subcorneal blisters filled with polymorphonuclear leukocytes and which affected mainly middle-aged women. A case of this type was observed recently at the Detroit Receiving Hospital and is reported here so that others may recognize the disease more readily.

The cases of Sneddon and Wilkinson were felt to be distinct from dermatitis herpetiformis, although there were similarities. The pustules were sterile, had some tendency to grouping, were accompanied by moderate to severe pruritus and some hyperpigmentation. They responded fairly well to sulfapyridine and the sulfones. Cases similar clinically and histologically were reported by Hellier,2 whose case eventuated from a pustular eruption of the palms and soles, and by Duperrat,3 who felt that his case was not related to Duhring's disease. Other similar cases have been

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