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November 1958

Dyskeratosis Ichthyosiformis Congenita Migrans: A Variant of Congenital Ichthyosiform Erythroderma

Author Affiliations

Belgrade, Yugoslavia

From the Department of Dermatology and Syphilology, University of Belgrade (Prof. S. Hié, M.D., Head).

AMA Arch Derm. 1958;78(5):625-629. doi:10.1001/archderm.1958.01560110071010

An interesting clinical picture characterized by slowly extending serpiginous and polycyclic lesions with raised edges, hyperkeratosis of the flexures, and hyperhidrosis of the palms, present from birth, in a woman aged 23, was first described by Comel,1 in 1949. The back, abdomen, and proximal parts of the extremities were mainly involved; the condition became more pronounced at puberty, but there were subsequently some remissions. Comel suggested the term "ichthyosis linearis circumflexa."

In a review of the literature we were able to find only one further case report under this diagnosis. Frank's2 patient (1956), a man, showed almost identical clinical features. The condition had appeared within the first three months of life and had persisted.

We believe that the cases presented by Miescher,3 in 1954,

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