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November 1958

Treatment of Psoriasis with Riboflavin

Author Affiliations

Pawtucket, R. I.; Providence, R. I.

From the Department of Dermatology, Boston University School of Medicine (Herbert Mescon, M.D., Professor); Assistant Clinical Professor of Dermatology (Dr. Schiff) and Assistant Clinical Professor of Dermatology (Dr. Kern).

AMA Arch Derm. 1958;78(5):643. doi:10.1001/archderm.1958.01560110089016

The therapeutic effects of riboflavin in psoriasis have recently been studied by several investigators. Their results are rather varied. Luscombe1 reported marked improvement in 45% and improvement in 43% of the cases he followed and concluded that this form of therapy was a welcome addition to our armamentarium. Sulzberger and Baer,2 who prescribed riboflavin by mouth to a great number of psoriatic patients, did not observe any significant improvement. Welsh and Ede3 administered riboflavin orally and parenterally to a group of 348 patients with psoriasis but failed to produce any noticeable response. We studied a series of psoriatics to whom riboflavin was given orally and parenterally. The results are herewith submitted.

Ninety patients with chronic psoriasis were treated. Seventy-seven were given weekly injections of 1 cc. of aqueous solution containing 50 mg. of riboflavin-5-phosphate sodium (equivalent to riboflavin 35 mg.)* over a period ranging