Ehlers-Danlos' syndrome is a dysplasia of the mesenchymal tissue characterized by abnormal hyperlaxity and elasticity of the skin; dermofragility, or easy bruising and splitting of the skin at the slightest provocation, with formation of deep wounds, hematomas, and pseudotumors, and, finally, hyperlaxity of the joints. Tobias10 and others8 suggested that the symptoms were manifestations of a generalized mesenchymal anomaly with changes in the connective tissue in skin, tendons, joint capsules, large vessels, and internal structures. Publications based on necropsy findings in Ehlers-Danlos' syndrome have not been found in the literature, and definite proof of a universal mesenchymal anomaly is lacking. Tscherno-Gubow first described the condition in 1892, whereas Ehlers4 made his report in 1901 and Danlos,3 in 1908, respectively.
Most cases occur in isolation,1,3-5,7,8,10,12, 17-19 and some authors consider the condition a recessive one. Others, as Wiener12 and