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December 1958

Clinical Enzymology

AMA Arch Derm. 1958;78(6):795. doi:10.1001/archderm.1958.01560120115027

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This volume heralds the approach of a new type of medicinal chemistry—one that in the future will "startle the world of classical biology." All phases of clinical enzymology are given consideration in this book; chemistry, biochemistry, much clinical data, laboratory diagnostics, therapeutic effects and even a look into the future with regard to the parenteral use of enzymes in disease. Topical use is not reviewed.

The idea of "biological relativity" is developed in a manner which is similar to Einstein's theory of relativity in the field of physics. According to this, no enzyme has only one function, its functions depend rather on its environment and are relative to the substrate that presents itself. No ion or molecule can be added to a biological system without modifying the behavior of every component of the system. Then follow chapters on the biochemistry of enzymes, the parenteral use of enzymes in various

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