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January 1959

The Basal-Cell Nevus: Its Relationship to Multiple Cutaneous Cancers and Associated Anomalies of Development

Author Affiliations

Dallas, Texas; Chicago

AMA Arch Derm. 1959;79(1):67-80. doi:10.1001/archderm.1959.01560130069008

The basal-cell nevus is a dysgenetic dermatosis characterized by multiple small cutaneous tumors. These are histologically indistinguishable from basal-cell cancer. Malignant supervention is common, generally resulting in multiple basal-cell cancers of the face in young adults. Developmental defects of other systems are often present. Incidence seems to be based on an inherited, sometimes familial, predisposition.

Clinical Features

Basal-cell nevi may appear at birth or be first noted in infancy. Occasionally the lesions may begin at about puberty and gradually increase in number and in size over a period of years. There may be few or hundreds, and there is a tendency for bilateral distribution, but this need not be symmetrical. The size of the individual lesion varies from that of a pinhead to approximately 5 mm. in diameter. Pedunculated and papular lesions are common on the neck, eyelids, and axillae.

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