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January 1959

Prednisolone in Aerosol Form

AMA Arch Derm. 1959;79(1):103. doi:10.1001/archderm.1959.01560130105015

A prednisolone (Meti-Derm) aerosol, containing 50 mg. of prednisolone, isopropyl myristate, and Freon as a propellant* was used in 109 patients

The following patients were treated: 62 with contact dermatitis, 17 with atopic dermatitis, 16 with seborrhoic dermatitis, 6 with pruritus ani, 2 with circumscribed neurodermatitis, 2 with dyshidrotic eczema, 1 with eczema scroti, 1 with pruritic psoriasis, 1 with essential pruritus, and 1 with otitis externa eczematosa.

Patients applied the spray at least twice daily and oftener, as needed, when itching was severe. Spraying the affected area for three seconds delivers approximately 0.5 mg. of prednisolone.

Results were good (both subjective and objective improvement) in 63 patients and fair (relief from itching only) in 26 patients, or 82% over-all improvement. Nineteen patients showed no response. In one case of essential pruritus, itching increased, but sensitivity did not occur in a single instance. Of 61 patients who were

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