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January 1959

Prednisolone (Meti-Derm) as an Aerosol for Dermatoses

AMA Arch Derm. 1959;79(1):103-105. doi:10.1001/archderm.1959.01560130105016

Topical applications of hydrocortisone1 and, more recently, prednisone or prednisolone2-4 are widely used in the treatment of many types of dermatologic disease. A new vehicle for prednisolone (Meti-Derm) aerosol with 50 mg. of the steroid, isopropyl myristate, and Freon as a propellant, in a 150 gm. spray applicator, was made available to us for clinical study. A three-second spray delivers approximately 0.5 mg. of prednisolone.


This series consisted of 79 patients with dermatologic disease, most commonly eczema of various types, including eczematous dermatitis. Patients were instructed to apply the aerosol to lesions in very short bursts of spray from a distance of 1 to 2 in. Examinations were made weekly and progress noted. No other therapy was used.

Results were graded as "excellent" if lesions involuted promptly and completely, "good" if response was somewhat slower or not complete, "fair" if some

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