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January 1959


AMA Arch Derm. 1959;79(1):108-111. doi:10.1001/archderm.1959.01560130110018

Ichthyosis (Result of Treatment with a 10% Sodium Chloride Ointment). Presented by Dr. Irwim I. Lubowe and Dr. Edward H. Mandel.

A 5-year-old boy has had a generalized skin eruption since birth. A maternal uncle had a similar condition. No other members of the family are affected.

The eruption consists of dry scaling in the characteristic fashion of ichthyosis.

The patient applied 10% sodium chloride in hydrophilic ointment to the right upper and lower extremities daily for about three months. The other limbs were left untreated. There is marked improvement on the treated side.


Dr. Hyman Gordon (by invitation): In the Acta medica scandinavica (108:98, 1941) Ljungstrom reported "A Simple and Effective Treatment of Ichthyosis." Observing that a 22-year-old man with ichthyosis hystrix was free of lesions in the axillae, where he sweated profusely, Ljungstrom reasoned that sodium chloride could be the preventive or improving agent

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