The objective of this paper is to present data regarding the immunology of three cutaneous viral diseases. These data will be used as the basis for a brief discussion of certain methods of treatment of these diseases.
A proper concept of the host-parasite relationship in herpes simplex infections is basic to an understanding of the immunology of this disease. The virus makes its original invasion between the ages of 1 and 5 years in a majority of persons. The usual manifestation at this time is a subclinical gingivostomatitis. Occasionally, the local symptoms are severe and require medical attention. Rarely, the virus invades the inflamed skin of a patient with a preexisting dermatitis. This latter syndrome is called eczema herpeticum. Because of the massive nature of the onslaught, toxic symptoms are more pronounced.
After this initial penetration, the virus goes into a latent state in a localized area
BALDRIDGE GD. Immunologic Aspects of Herpes Simplex, Herpes Zoster, and Vaccinia. AMA Arch Derm. 1959;79(3):299–304. doi:10.1001/archderm.1959.01560150041006
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