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March 1959

Disseminated Granuloma Annulare: Report of a Case Treated with Chloroquine Phosphate (Aralen)

AMA Arch Derm. 1959;79(3):352-353. doi:10.1001/archderm.1959.01560150094015

The literature has been reviewed, and there are no reports of treatment of disseminated granuloma annulare with chloroquine phosphate (Aralen).

The therapy of localized granuloma annulare is varied, and the response in each patient is unpredictable. A method of treatment may induce immediate clearing of the lesions of one patient, whereas the identical treatment in another patient will not affect the course of the eruption. Superficial x-ray, intradermal injections of hydrocortisone or prednisolone, solid carbon dioxide (Dry Ice) applied to the lesions, scalpel incisions of the papules, and punch biopsy of a papule have produced involution of the eruption. Spontaneous remission can also occur. Disseminated granuloma annulare has been treated successfully with intramuscular injections of either streptomycin1 or bismuth.2

Report of Case

A white man, aged 26, first noticed the appearance of skin lesions on his buttocks in April, 1956. Within one