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April 1959

A Histochemical Study of Hyperkeratoses: Nucleic Acids, Carbohydrates, and Sulfur Compounds

Author Affiliations

From the Medical Service, Section of Dermatology, Veterans Administration Hospital, and the Department of Medicine, Division of Dermatology and Syphilology, State University of New York College of Medicine at New York City.

AMA Arch Derm. 1959;79(4):436-443. doi:10.1001/archderm.1959.01560160054006

In a previous study the stratum corneum of parakeratotic lesions was found to contain more sulfhydryl and less disulfide than normal. Furthermore, mucoprotein substances could be demonstrated in the pyknotic nuclei. Also, occasionally small clumps of these substances were seen in the parakeratotic layers. Finally, the parakeratotic strata seemed to contain ribonucleic acid.

The present study was undertaken for the purpose of investigating the nucleic acids, carbohydrates, and sulfur compounds in hyperkeratoses and to compare the findings with those in parakeratoses.

Material and Methods

The material examined included (1) inflammatory lesions (lichen planus, acute and chronic dermatitis, lupus erythematosus discoides, pityriasis rosea); (2) proliferative lesions (calluses, seborrheic keratoses, keratotic nevi, verrucae vulgares, verrucae planae, papillomas, condylomas); (3) ichthyosis vulgaris, and (4) premalignant lesions (senile keratoses, leukoplakias, and x-ray keratosis). It was thought that this selection might disclose specific histochemical characteristics of

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