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April 1959

The Reduction of Gonadal Dose in Dermatologic Radiotherapy

AMA Arch Derm. 1959;79(4):449-454. doi:10.1001/archderm.1959.01560160067008

There is a need for more definite information regarding the rate of genetic mutations occurring in man and the sensitivity to ionizing radiations. Although genetic mutations may occur spontaneously, there are several factors that are known to increase the rate of mutations. Ultraviolet light and heat are two of these. Recently Ehrenberg et al.1 showed that today's mode of dress for men increases the testicular temperature. They found a difference of at least 3 C between clothed and disrobed states. They also postulated that almost half of the present load of spontaneous mutations might be due to the mode of dress for the past two centuries. Further, the heat factor might imply genetical hazards 100-1,000 times greater than those estimated from various sources of ionizing radiation.

Ionizing radiation can produce genetic mutations, and there is no threshold dose for ionizing radiation below which mutations