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April 1959

Oxytetracycline Hydrochloride-Polymyxin B Sulfate Topical Powder: Used in Over 5,000 Patients Without Significant Allergic Reactions

Author Affiliations

Greensboro, N. C.

AMA Arch Derm. 1959;79(4):455-457. doi:10.1001/archderm.1959.01560160073009

A few years ago, it was frequently heard that antibiotics used systemically should not be used topically for fear of sensitizing the patient to the medication, thereby depriving him of its systemic use at a later date. This statement proved true, in the experience of most physicians, in regard to the topical use of penicillin and sulfonamides in adults; but most antibiotics, which have subsequently come into general use, seem to cause very little cutaneous sensitization.

The experiences reported herewith deal with the local use of oxytetracycline hydrochloride mixed with polymyxin B sulfate.* According to the manufacturer, the exact formula in the preparation of 1,000 gm. of the powder is as follows: Gm. Oxytetracycline hydrochloride 33.09 Polymyxin B sulfate 1.44 Lactose, U. S. P. 965.47 The formula is based on a potency of 925 units per milligram plus a 2% overage of oxytetracycline hydrochloride and 7,100 units per

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