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May 1959

Treatment of Acute Parapsoriasis with Corticotropin (ACTH): Report of a Case

Author Affiliations

Rochester, Minn.

AMA Arch Derm. 1959;79(5):512-515. doi:10.1001/archderm.1959.01560170010002

Acute guttate parapsoriasis, or pityriasis lichenoides et varioliformis acuta of Mucha-Habermann, is an entity better known for the length of its name than for the importance of any clinical information concerning it. Our studies in the past several years, and recently those of Piérard and Van Steenbergen,1 have led us to the conclusion that microscopic hemorrhage is the typical histologic finding in this entity and that the hemorrhage occurs on the basis of intense inflammation of capillaries. Szymanski2 recently discussed a large series of these cases on the basis of allergic angiitis as the etiologic factor. The variable clinical lesions could be explained on such a basis.

While this progress in the basic understanding of some of the clinical and histopathologic features of the disease was being made, no progress in treatment has been recorded for many years. Canizares3 reported success with

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