A persistent penile plaque without skin involvement elsewhere on the body presents a puzzling problem. One must rule out erythroplasia of Queyrat by biopsy, since benign lesions may clinically give the same appearance. Blau and Hyman1 point out that three diagnoses can be made histopathologically. They are Bowen's disease of mucous membrane (erythroplasia of Queyrat), benign inflammatory dermatoses of the mucous membrane, or plasmacytoma penis.
Fournier and Darier,2 in their original description of erythroplasia, separated the disease into a benign and malignant type, depending on the presence or absence of malignant dyskeratoses. Nevertheless, the term erythroplasia has become synonymous with precancerous lesion requiring radical removal. Sachs and Sachs,3,4 although retaining the term, have successfully treated lesions with neoarsphenamine topically, thus denoting the benign character of the lesions. Sulzberger,5 in his excellent article on persistent penile plaques, gives the history of
WILLIAM B. REED. Erythroplasia of QueyratReport of a Case with Recurrence After Cessation of Topical Hydrocortisone. AMA Arch Derm. 1959;79(5):587–589. doi:10.1001/archderm.1959.01560170085013