Oligophrenia, Ichthyosis, and Spastic Diplegia. (?Sjogren-Larsson Syndrome). Presented by Dr. Chester Frazier.
A boy aged 23 months has been followed since the age of 9 months at Children's Hospital because of cerebral palsy and mental retardation. Four weeks ago he was admitted to Massachusetts General Hospital with a clearing eruption of chickenpox and generalized convulsions. In September, 1957, he had had a seizure with acute laryngotracheobronchitis. Until his admission he had had no anticonvulsant therapy. The patient's skin was normal at birth, but he later developed a scaly eruption on the legs, with dry skin elsewhere.
There is an area of pronounced scaling on both legs, giving the appearance of an alligator-like skin. The scales themselves are 1 to 2 cm. in diameter.
The patient is within the normal percentile of growth and development curves. Roentgenograms of the skull and an electroencephalogram were normal. The blood sugar
Tolman MM, Catinella PJ. NEW ENGLAND DERMATOLOGICAL SOCIETY. AMA Arch Derm. 1959;79(5):607–611. doi:10.1001/archderm.1959.01560170105025
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