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May 1959


AMA Arch Derm. 1959;79(5):607-611. doi:10.1001/archderm.1959.01560170105025

Oligophrenia, Ichthyosis, and Spastic Diplegia. (?Sjogren-Larsson Syndrome). Presented by Dr. Chester Frazier.

A boy aged 23 months has been followed since the age of 9 months at Children's Hospital because of cerebral palsy and mental retardation. Four weeks ago he was admitted to Massachusetts General Hospital with a clearing eruption of chickenpox and generalized convulsions. In September, 1957, he had had a seizure with acute laryngotracheobronchitis. Until his admission he had had no anticonvulsant therapy. The patient's skin was normal at birth, but he later developed a scaly eruption on the legs, with dry skin elsewhere.

There is an area of pronounced scaling on both legs, giving the appearance of an alligator-like skin. The scales themselves are 1 to 2 cm. in diameter.

The patient is within the normal percentile of growth and development curves. Roentgenograms of the skull and an electroencephalogram were normal. The blood sugar

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