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June 1959

Electrophoretic Patterns in Psoriatic Exfoliative Erythroderma: Effects of Gamma-Globulin in Treatment of Psoriasis

Author Affiliations


From the Department of Dermatology, University of Pennsylvania School of Medicine.

AMA Arch Derm. 1959;79(6):641-643. doi:10.1001/archderm.1959.01560180015004

In 1949, Klinck1 reported encouraging results with λ-globulin in the treatment of six patients with psoriasis. Studies were not done to estimate the amount of λ-globulin in the blood of any of the patients before, during, or after treatment.

The purpose of the present study is to evaluate the efficacy of λ-globulin in the treatment of severe forms of psoriasis. During this treatment we also determined electrophoretic patterns in selected cases.

Method of Study

Five patients were chosen for this study. Four patients had psoriatic exfoliative erythroderma of one to three years' duration. One patient for many years had severe generalized psoriasis, recalcitrant to all previous forms of therapy. Electrophoretic tracings were carried out before, during, and after treatment to ascertain changes in the electrophoretic patterns.

Poliomyelitis-immune globulin,* containing 165 ±15 mg. per cubic centimeter of the globulin fraction of pooled normal human plasma, was administered in

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