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June 1959

The Treatment of Alopecia Universalis with Methyl Prednisolone (Medrol): Associated with Vitiligo Involving Arms, Forearms, Neck, and Thigh

AMA Arch Derm. 1959;79(6):665-668. doi:10.1001/archderm.1959.01560180039012

I have described previously in three articles1,2,5 the treatment of alopecia areata, universalis, and totalis by the cautious use of cortisone, hydrocortisone, and their analogues, prednisone and prednisolone. In the later report,2 I tabulated the result of treatment of 68 patients with alopecia areata, totalis, and universalis with methyl prednisolone (Medrol*). In a recent communication4 in the Archives I have also suggested the possible pathogenetic relationship between hypopigmentation and melanocyte formation associated with alopecia areata and totalis. The duration of the alopecia ranged from 3 months to 25 years. I concluded that 62% of the male patients had complete regrowth and 38% had partial regrowth; also 58% of the female patients had complete regrowth, and 42% had partial regrowth.

In conjunction with the intake of methyl prednisolone orally, regular periodic intra-muscular injections of corticotropin (ACTH) are given weekly at

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