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To the Editor:—On May 10, 1906, thus 53 years ago, an article entitled ``Eine Serodiagnostische Reaktion bei Syphilis" appeared in the Deutsche medizinische Wochenschrift. The method was introduced by Wassermann, Neisser, and Bruck and was based on the ingenious principles of Bordet and Gengou's complement fixation. It was an indirect method of detecting the antibody in syphilis, the direct methods dealing with the treponemata at that time having failed. The importance of this diagnostic aid in the discovery and control of syphilis can never be estimated.
The complications encountered in the performance of this complicated test led to numerous modifications, as well as to simplifications. In December, 1908, Dr. Hugo Hecht, then at Prague and now at Cleveland, published a preliminary paper under the title, "A Simplification of the Complement Fixation Test for Syphilis." This was followed within a few months by a second article. In May, 1910,
Ecker EE. THE HECHT TEST FOR DETECTING THE ANTIBODY IN SYPHILIS. AMA Arch Derm. 1959;79(6):722–723. doi:https://doi.org/10.1001/archderm.1959.01560180096027
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