Shortly after histamine was first synthesized by Windaus and Vogt, in 1907,1 its physiologic properties were described by Dale and Laidlaw,2 who at the same time called attention to the similarity between the symptoms produced by administration of histamine and those of anaphylaxis. Later, Lewis3 observed that when stimuli of different kinds were applied to the skin, all elicited a common type of response, which he termed the "triple response." Noting the similarity between that response and histamine-induced wheals, he postulated that the triple response must be due to the liberation by injured cells of a histamine-like substance, which he called "H-substance." Much investigation has ensued in attempts to substantiate histamine as the chemical mediator of anaphylaxis in animals and of allergy in man. Since many dermatologic conditions are partially or totally allergic in origin, estimates have been made of the metabolism of histamine
SCHULTZ HJ, CODE CF, BRUNSTING LA. Blood Histamine and Basophil-Eosinophil Counts in Skin Diseases. AMA Arch Derm. 1959;80(1):44–52. doi:https://doi.org/10.1001/archderm.1959.01560190046006
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