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July 1959

Investigations on the Effect of Psoralen Derivatives on Blood Sugar and Glutathione

Author Affiliations

Cairo, Egypt

AMA Arch Derm. 1959;80(1):53-55. doi:10.1001/archderm.1959.01560190055007

Since 1948, new drugs, psoralens (Ammoidin and Ammidin, which are 8-methoxypsoralen and 5-isoamyleneoxypsoralen, respectively), separated in crystalline form from the extracts of the fruits of an Egyptian herb, Ammi majus linn,1 have been used with success by one of us (A. M. E-M.) in 19482,3 and 1949 in the treatment of leukoderma. Since then, many investigators4-6 have tried these drugs in the treatment of leukoderma, and they have confirmed its successful results.

In our trials on these drugs for the last 10 years we were fully aware of the importance of detecting and reporting any undesirable side-effects.

The possibility of a potential danger of aggravating a diabetic process was raised when one of us (A. M. E-M., 19528) reported two cases of mild diabetes where a possible aggravation of their diabetes was clinically suspected. One of these cases was a dentist, treating