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July 1959

Familial White Folded Dysplasia of the Mucous Membranes

Author Affiliations

New York

From the Division of Stomatology, School of Dental and Oral Surgery of the Faculty of Medicine, Columbia University, New York; the Department of Periodontology, University of Oregon Dental School, Portland, Ore., and the Institute of Cancer Research, Columbia University College of Physicians and Surgeons, New York.

AMA Arch Derm. 1959;80(1):59-65. doi:10.1001/archderm.1959.01560190061009

In 1935, Cannon1 first called attention to a syndrome which he described as a white spongy nevus of the oral mucosa. A detailed review of the medical and dental literatire since that time has revealed 10 additional reports dealing with such a congenital disturbance of the oral mucous membranes. It has been variously termed "congenital leukeratosis of the oral mucosa" by Ludy and Shirazy,2 "pachyderma oralis" by Kinney and Derifield,7 and "white folded gingivostomatosis" by Everett and Noyes,5 Orban and Wentz,6 and Darling and Fletcher.12 Cooke8,9 described two similar cases as "oral epithelial nevi." Lesions in the same patient in areas other than oral (dermal, vaginal, or rectal) have been documented in several of these reports.5,11 A total of 15 cases have been actually observed and described in detail previously. Our review of the literature