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July 1959


AMA Arch Derm. 1959;80(1):102-107. doi:10.1001/archderm.1959.01560190104021

Diagnosis: Cutaneous Leishmaniasis (Treated with Dihydrostreptomycin). Presented by Dr. Laurence L. Palitz.

A 62-year-old woman came to this country four years ago from central Italy where she was born. Eighteen months ago she first noted on her nose a small "pimple" which "never came to a head." This lesion was removed by a dermatologist, and one diagnosis was "possible histoplasmosis" because histopathology was compatible and because histoplasmin tests were positive. The patient was first seen by me in April, 1958, at which time she presented a large ill-defined, raised, verrucous plaque covering the entire top of the nose. Part of the lesion was covered with a brownish-yellow adherent crust. Biopsy at this time revealed a granulomatous reaction with a dense cellular infiltrate throughout the entire cutis. The infiltrate was made up of lymphocytes, plasma cells, and large mononuclear cells, containing closely packed organisms which were identified as Leishmania

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