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September 1959

Chromoblastomycosis Treated by Vibrapuncture Injection of Amphotericin B

Author Affiliations

New Orleans

From the Division of Dermatology, Department of Medicine, and from the Department of Microbiology, Tulane University School of Medicine.

AMA Arch Derm. 1959;80(3):286-287. doi:10.1001/archderm.1959.01560210028006

Chromoblastomycosis, although not one of the fatal fungus diseases, is sufficiently disfiguring to demand treatment. In the past year, we have had success in treating a case of this disease with amphotericin B, with use of the vibrapuncture technique.

Report of a Case

A 74-year-old Negro farmer presented himself to the Tulane Dermatology Service on March 18, 1958, with a granulomatous lesion of the left wrist, present for 11 months. It was ellipsoidal in shape; the semimajor axis was 5 cm. in length; the semiminor axis was 2.5 cm., and the area thus was approximately 39.3 sq. cm. There was central clearing. The borders were verrucous in some places and scaly in others. The lesion was infiltrative throughout much of its extent.

Scraping of the lesion disclosed the characteristic septate bodies of chromoblastomycosis. The fungus culture was identified as Hormodendrum pedrosoi. The biopsy specimen was read by