One of the problems in persons with "chataigne," or farmer's, type of skin is the continuous development of senile keratoses and the frequent malignant transformation of these keratoses following chronic exposure to sunlight. Recent experience with two patients suggests that chloroquine may be a partial inhibitor of this process.
The usefulness of antimalarial drugs in the treatment of lupus erythematosus has been known for several years now.1 More recently, these drugs have been found to be effective therapeutic agents for polymorphic light-sensitivity eruptions.2,3 In 1957, two albino Negro women reported to the Dermatology Clinic at Jefferson Davis Hospital for treatment of discoid lupus erythematosus and a chlorpromazine photosensitivity, respectively. Both had advanced actinic degeneration and numerous senile keratoses in exposed areas. The patients were followed at regular intervals for the keratotic lesions, as well as for their primary condition.
Report of Cases
KNOX JM, GUIN JD. The Effect of Systemic Chloroquine Therapy on Actinic Keratoses: Report of Two Cases in Albino Negroes. AMA Arch Derm. 1959;80(3):347–348. doi:https://doi.org/10.1001/archderm.1959.01560210089019
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