Diagnosis: Chronic Bullous-Ulcerative Disease. Presented by Dr. Frank E. Cormia.
Dr. Abraham J. Orfuss: In looking over the protocol I saw no indication that the λ-globulin determination was done.
Chairman Barker: The cryoglobulins were negative.
Dr. Orfuss: The λ-globulins.
Dr. Frank E. Cormia: She had a starch gel electrophoresis pattern, and the λ-globulins are normal.
Dr. David Bloom: In spite of a normal λ-globulin in the serum, I should suggest the diagnosis of pyoderma gangrenosum, which is very frequently associated with arthritis and not necessarily with ulcerative colitis. I believe that the patient will benefit by a strongly supportive therapy. Even λ-globulin injections may be of benefit in spite of a normal content in the serum.
Dr. Beatrice Kesten: I agree with Dr. Bloom that this belongs in the group of allergic vasculitis, namely, dermatitis nodularis necrotica. The psychogenic aspects are probably secondary. She has sinusitis and
Barker L, Sobel N. NEW YORK ACADEMY OF MEDICINE, SECTION OF DERMATOLOGY AND SYPHILOLOGY. AMA Arch Derm. 1959;80(3):376–377. doi:10.1001/archderm.1959.01560210118026
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