Previous studies employing treponemal antigens on spinal fluid have dealt for the most part with the Treponema pallidum immobilization (TPI) procedure of Nelson. Nelson and his co-workers1 observed positive reactions in all of 33 patients with various types of central nervous system (CNS) syphilis. Interestingly enough, of 25 patients classified as latent syphilis, 6 showed TPI antibody in the spinal fluid. Durel and his co-workers2 observed only 78% positive TPI reactions in a group of 54 spinal fluids of patients with neurosyphilis. Of 25 patients classified as latent syphilis, 7 were found to have positive TPI tests on the spinal fluid. Zellman and Lutz3 observed a similar sensitivity of 77% in a group of 26 patients with CNS syphilis. Again, 4 of 11 patients with supposed latent syphilis had positive TPI tests on the spinal fluid. These workers conclude that in neurosyphilis the TPI antibody
KOSTANT GH, LANDY SE, MILLER JN, KELCEC LC. Treponemal Tests on Cerebrospinal Fluid: Experiences with the Treponema Pallidum Complement-Fixation (TPCF) and Reiter Protein Complement-Fixation (RPCF) Tests. AMA Arch Derm. 1959;80(4):439–441. doi:10.1001/archderm.1959.01560220049010
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