[Skip to Navigation]
October 1959

Treponemal Tests on Cerebrospinal Fluid: Experiences with the Treponema Pallidum Complement-Fixation (TPCF) and Reiter Protein Complement-Fixation (RPCF) Tests

Author Affiliations

New York; Los Angeles; New York

From the Department of Dermatology and Syphilology of the New York University Post-Graduate Medical School (Dr. Marion B. Sulzberger, Chairman) and the Skin and Cancer Unit of the New York University Hospital (Drs. Kostant, Landy, and Kelcec); from the Department of Infectious Diseases, University of California Medical Center, School of Medicine (Dr. Miller).

AMA Arch Derm. 1959;80(4):439-441. doi:10.1001/archderm.1959.01560220049010

Previous studies employing treponemal antigens on spinal fluid have dealt for the most part with the Treponema pallidum immobilization (TPI) procedure of Nelson. Nelson and his co-workers1 observed positive reactions in all of 33 patients with various types of central nervous system (CNS) syphilis. Interestingly enough, of 25 patients classified as latent syphilis, 6 showed TPI antibody in the spinal fluid. Durel and his co-workers2 observed only 78% positive TPI reactions in a group of 54 spinal fluids of patients with neurosyphilis. Of 25 patients classified as latent syphilis, 7 were found to have positive TPI tests on the spinal fluid. Zellman and Lutz3 observed a similar sensitivity of 77% in a group of 26 patients with CNS syphilis. Again, 4 of 11 patients with supposed latent syphilis had positive TPI tests on the spinal fluid. These workers conclude that in neurosyphilis the TPI antibody

Add or change institution