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October 1959

Pathological Changes Associated with Aluminum and Zirconium Compounds: An Experimental Study of Skin Pathology Following the Application of Aluminum Chlorohydroxide, Aluminum Sulfate, Sodium Aluminum Lactate, and Zirconium Tetraisopropoxide

Author Affiliations

Syracuse, N. Y.

From the Department of Pathology and Medicine, State University of New York, Upstate Medical Center.

AMA Arch Derm. 1959;80(4):447-454. doi:10.1001/archderm.1959.01560220057013

In an earlier study performed in this laboratory, it was demonstrated that sodium zirconium lactate, which was used in commercial deodorants, would uniformly produce inflammatory changes in the skin of rabbits with ultimate granuloma formation.1 This study has now been extended to include observations on two other chemicals used in commercial deodorants—aluminum chlorohydroxide and aluminum sulfate—and two chemicals with deodorant possibilities— sodium aluminum lactate and zirconium tetraisopropoxide.

Methods and Materials

Albino rabbits approximately 4 months of age and weighing 1,500 to 2,000 gm. were used in these experiments. The test chemicals were administered by three basic routes as follows: subcutaneous (0.5 ml. of the chemical in solution), using the skin of the rabbit's back from which the hair had been removed by electric clippers; intracutaneous (0.1 ml. of the test solution), using the skin on the inner aspect of the rabbit's ear, which is usually covered