In general, allergic cutaneous sensitivity reactions, after the topical application of neomycin, are considered to be rare. Baer and Ludwig1 reported the first case of contact sensitivity to neomycin. Sulzberger and Baer2 stated that they occasionally saw contact sensitivity to this antibiotic. Epstein3,4 was the first to report a series of patients with neomycin sensitivity. However, his patients did not present the typical and easily recognizable picture of contact dermatitis. In the majority of cases which he reported, for the most part, the diagnosis depended upon a heightened index of suspicion, rather than on the easy recognition of the classical clinical features of an acute contact dermatitis. In this series, Epstein was of the opinion that he proved the etiological role of neomycin by the demonstration of positive intradermal tests to the antibiotic. Patch tests with neomycincontaining ointments and/or 10% solution of
REYNOLDS H, HILDEBRAND JF, LIVINGOOD CS, FOSNAUGH RP. Clinical Features of Contact Dermatitis Due to Neomycin: Report of Cases. AMA Arch Derm. 1959;80(4):455–460. doi:10.1001/archderm.1959.01560220065014
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