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October 1959


AMA Arch Derm. 1959;80(4):486-490. doi:10.1001/archderm.1959.01560220096021

I. Autoerythrocyte Sensitization. Presented by Dr. R. C. Griggs and Dr. W. F. Dowdell (by invitation).

A 39-year-old housewife had recurrent episodes of purpura since 1953. These started after an apparently routine appendectomy. The lesions are characterized by the following course: She first notices a tingling sensation in an area of her skin; within 24 hours there appears an erythematous, slightly raised area, which rapidly becomes purpuric and usually rather painful. These areas often occur at the time of menstruation and on all areas of the trunk and extremities, primarily the upper legs.

In association with these lesions she has frequently had abdominal pain, hematuria, intestinal obstruction, melena, and, recently, periods of unconsciousness.

During the time of exacerbation there are numerous purpuric areas on the legs, varying from 1 to 10 cm. in diameter, often with a clear center.

Repeated blood cell counts, platelet counts, and

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