Colloid degeneration of the skin is an uncommon condition characterized clinically by the development of pseudovesicles in light-exposed areas. Approximately 84 cases have been reported since the entity was originally described, by Wagner, of Leipzig, in 1866.1 We do not believe the condition is as rare as the sparsity of reports would indicate. We have collected seven cases over a six-year period and have seen several other unreported cases at meetings held in this area. Hand2 saw three Australian soldiers with colloid degeneration within a year, and Gilbert and Cox3 found this entity in eight soldiers over a three-month period. This unusually high incidence was undoubtedly due to the amount of sunlight exposure of the Australian troops in Northern Australia, New Guinea, and Borneo.
Colloid milium is found most often in fair-skinned persons who are chronically exposed to sunlight. The ratio of males
GUIN JD, SEALE ER. Colloid Degeneration of the Skin (Colloid Milium): A Report of Seven Cases. AMA Arch Derm. 1959;80(5):533–537. doi:https://doi.org/10.1001/archderm.1959.01560230019003
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