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November 1959


AMA Arch Derm. 1959;80(5):621-625. doi:10.1001/archderm.1959.01560230107033

Acrodermatitis Enteropathica, with Familial Incidence of Acrodermatitis Enteropathica and Moniliasis. Presented by Dr. Walter F. Lever.

A white infant girl, one year old, is presented from the Children's Medical Center, Boston, with an eruption which has been present since the age of 2 months. The rash began around the mouth and chin, and later appeared around the vulva and anus. Its outbreak was associated with diarrhea. It consists of discrete patches, red, oozing, and denuded, with superficial yellow crusts.

Candida albicans was cultured from the lesions. Blood counts and urinalyses were normal. The blood calcium was 9.8 mg. per 100 cc., phosphatase 5.9 mg., sodium and potassium normal. The serum protein was 7.2 gm. per 100 cc., with albumin 5.2 gm., γ1 5, γ2 19, β 12, a 13.

The eruption cleared dramatically with the administration of Diodoquin orally, 1/2 tablet t.i.d. The diarrhea and "fussiness"

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