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January 1960

Verruciform Manifestations of Keratosis Follicularis: Including a Reappraisal of Hard Nevi (Unna)

Author Affiliations

Tampa, Fla

AMA Arch Derm. 1960;81(1):1-14. doi:10.1001/archderm.1960.03730010005001

Frequently in keratosis follicularis (Darier's disease) verruciform papules, resembling verruca plana, occupy the dorsal surfaces of the hands and feet, quite distinctive from the typical papules of keratosis follicularis disseminated elsewhere over the body. The extensive foreign literature on keratosis follicularis takes appropriate note of this peculiar association of unlike lesions, but little mention of it is carried in the dermatologic literature of the English language. This report will deal with the clinical and histopathologic characteristics of these verruciform manifestations and their relationship to keratosis follicularis. Also, because of their similarity to so-called hard nevi (Unna), attention will be given to the differentiation of the two verruciform conditions, and evidence will be presented indicating that hard nevi are simply atypical variants of seborrheic keratoses.

Hopf1 in 1931 reported a verruciform dermatosis affecting the distal portions of the extremities, to which he gave the name acrokeratosis verruciformis. Unaccompanied by lesions

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