Although much is written concerning the malignant potential of nevi, little is to be found in the literature concerning their spontaneous involution.1 One can recognize the difficulty in learning the long-term natural history of these multiple, small, harmless lesions. Until recently a much larger and more dramatic lesion, the immature hemangioma, had a poorly discerned natural history. The literature seems to assume tacitly that nevi persist, never disappearing spontaneously. Yet patients from time to time assert that certain moles have faded away. Indeed once the physician's attention is directed to a depigmentary process about a nevus, he may find the mole itself will involute over a period of months or years. Thus, it can be seen that nevi may disappear, but in this instance with distinctive although poorly understood concomitant color change.2 Another clue concerning a potentially favorable prognosis for nevi is found in the literature concerning
SHELLEY WB. Photographic Evidence of the Spontaneous Involution and Disappearance of Pigmented Nevi: Case Report. AMA Arch Derm. 1960;81(2):208–209. doi:10.1001/archderm.1960.03730020044008
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