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February 1960

A New Local Anesthetic with Anticoagulant Properties: Chloroquine (Aralen) Dihydrochloride

Author Affiliations

New York

Assistant Attending Dermatologist, The Mount Sinai Hospital, New York.; Associate Clinical Professor of Dermatology, New York Medical College, Metropolitan Medical Center (Joseph Morse, M.D., Director).

AMA Arch Derm. 1960;81(2):260-263. doi:10.1001/archderm.1960.03730020096015

This is the first report of chloroquine (Aralen*) dihydrochloride as a local anesthetic and anticoagulant. Chloroquine is chemically unrelated to novocaine (procaine hydrochloride) or xylocaine (lidocaine) and, when injected intradermally or subcutaneously, produces prompt local anesthesia adequate for the performance of dermatological surgery. Prolonged bleeding occurs at the sites of injections and scalpel surgery.

Chloroquine (Aralen) was first introduced in this country as a result of the widespread screening program for antimalarial compounds undertaken during World War II.1 More recently, it has been employed therapeutically in a variety of dermatological conditions such as discoid lupus erythematosus2 and lichen planus.3 Thies4 has reported on the treatment of chronic discoid lupus erythematosus by local infiltration. In his cases, however, novocaine was injected simultaneously.

Chloroquine (7-chloro-4-[4-diethylamino-1-methylbutylamino] quinoline) is made available for parenteral administration as chloroquine (Aralen) dihydrochloride. The material used in this study was obtained in 3 cc. ampules,

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