In previous reports we have presented a general introduction to comparative canine and human dermatology1 and discussed mast cell disease in both species.2 In the latter report we noted the following:
Cystic rarefaction of the ischium, in one of our canine cases, which coincided closely to some reported cases of bone involvement in human urticaria pigmentosa.3
That the inability of canine mastocytoma to wheal on physical trauma may be a function of the large number of eosinophils present (their antihistamine content 4). Our attempts to correlate the wheal-inhibiting effect of eosinophils in several cases of human urticaria pigmentosa were inconclusive. This thesis shall be tested in a large series of cases.
That the presence of mast cells in viscera, bone marrow, etc., in mast cell disease (in either species) may not be evidence of metastasis, but may reflect an overgrowth of mast cells present
ORKIN M, SCHWARTZMAN RM. A Comparative Study of Canine and Human Dermatology: II. Cutaneous Tumors—Introduction and Discussion of Transmissible Reticulum-Cell Tumor. AMA Arch Derm. 1960;81(3):347–358. doi:10.1001/archderm.1960.03730030005001
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