It has been suggested by Liang and Cowdry1-3 that hair follicles are the primary site of neoplastic response when methylcholanthrene is applied to the skin of the mouse. Other investigators have emphasized the importance of the hair follicle in the development of tumors in the skin.4,5 Ghadially6 observed papillomas and keratoacanthomas arising from the pilosebaceous apparatus in the skin of rabbits treated with 9,10-dimethyl-1,2-benzanthracene.
Much confusion has arisen as to terminology for certain of these carcinogenic-induced tumors in the skin of experimental animals. Ghadially6 recently reviewed this problem, and showed the similarity of these experimentally-induced lesions in the rabbit to the keratoacanthoma that occurs spontaneously in man. He pointed out, "The present work leaves little doubt that a large majority of the so-called epitheliomas produced in rabbits by experimental cancer workers since experiments in chemical carcinogenesis commenced were in fact not true cancers but keratoacanthomas." During
RIGDON RH. Histopathogenesis of "Keratoacanthoma" Induced with Methylcholanthrene: Lesions in the Skin of Chicken. AMA Arch Derm. 1960;81(3):381–387. doi:10.1001/archderm.1960.03730030039006
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