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March 1960

Latex Slide Fixation Test in Dermatology

Author Affiliations


From the Department of Dermatology, College of Medicine, University of Cincinnati.

AMA Arch Derm. 1960;81(3):415-416. doi:10.1001/archderm.1960.03730030073011

Because of the continued interest and concern of the dermatologist in lupus erythematosus, he must be aware also of the developments in rheumatology. Frequently arthritis may precede the onset of the cutaneous phase of lupus erythematosus, and it is of interest to determine whether this is rheumatoid arthritis or that of lupus erythematosus. Many believe there are no significant differences in this arthritis. Laboratory tests have been of some help in this differential diagnosis. These tests include, of course, L.E. preparation, sensitized sheep red blood-cell agglutination for rheumatoid arthritis, etc. In general, these have been difficult to perform and have required trained personnel. Until recently, there was no fast, reliable screening test available for the diagnosis of rheumatoid arthritis.

In December, 1956, Singer and Plotz described the latex fixation test.1 The principle of the test is similar to that of current techniques for the diagnosis of rheumatoid arthritis by

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