Locally injected steroids have been reported useful in the treatment of many dermatologic and orthopedic maladies, but relatively little has been written about the local use of prednisolone. The latter preparation offers a distinct advantage over hydrocortisone in that the effective concentration is lower.1 This is particularly important in the treatment of lesions such as keloids, lichen planus, sarcoid, etc., where the amount of fluid that the lesion will hold is small, and a higher dose is desirable.
The local injection of hydrocortisone has been recommended in the treatment of selected cases of many dermatologic and orthopedic conditions. These include keloids, neurodermatitis of various types, necrobiosis lipoidica diabeticorum, psoriasis, discoid lupus erythematosus, lichen planus, granuloma annulare, cystic acne, localized myxedema, synovial cysts, ganglions, xanthoma tuberosum, chondrodermatitis nodularis chronica helicis, hidradenitis suppurativa, sarcoidosis, certain leukemic and lymphomatous infiltrates in the skin, and many other condition.2-4
Prednisolone acetate was administered intradermally
JERE D. GUIN, JOHN M. KNOX, MARVIN E. CHERNOSKY, EDWARD M. SHAPIRO. Prednisolone AcetateA Useful Steroid Preparation for Intradermal Administration. AMA Arch Derm. 1960;81(3):438–441. doi:10.1001/archderm.1960.03730030096016