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March 1960


AMA Arch Derm. 1960;81(3):489-490. doi:10.1001/archderm.1960.03730030147027

Polymorphic Light Eruption. Hartnup's Disease? Presented by Col. Raymond M. Williams (MC), U.S. Army, and Capt. Robert A. Neill (MC), U.S. Army (by invitation).  Two sisters, ages 7 and 12, both developed lesions on the face and all extremities at age 2½ years. The condition has been continuous since that time despite numerous attempts at treatment. Both children are allergic to penicillin. Four siblings are unaffected, but the mother apparently had a reaction to the sun for the first time about one month ago. One uncle has asthma.Prior to treatment both girls had intensely erythematous, papular, pustular, and excoriated lesions over the malar areas and lower foreheads, sharply demarcated superiorly and laterally. There was an erythematous papular eruption on the exposed parts of the lower and upper extremities with excoriation and scarring.Both girls have improved markedly on treatment during the past two months with amodiaquin (Camoquin), 100 mg. to 300 mg. daily, sun screening cream, and avoidance of sun exposure.Many laboratory studies have been done, all of which are negative or normal, including serum

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