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April 1960

Dermatologic Aspects of Modern Mesenchymology

Author Affiliations

Copenhagen, Denmark

From the University Clinic of Dermatology and Venereology, Rigshospitalet, Copenhagen, Denmark.

AMA Arch Derm. 1960;81(4):501-505. doi:10.1001/archderm.1960.03730040005001

Connective tissue is a biological system with abilities and reactivities of vital importance to the human organism's life and development.

The skin is connective tissue with an ectodermal cover. For years rheumatologists and ophthalmologists have been utilizing the flood of results obtained within the domain of connective tissue physiology. It is time now for dermatologists to take practical advantage of the theoretical and experimental progress in mesenchymology.

Biology of Dermis  Collagen, which constitutes an essential part of the extracellular fibrous material, is synthesized by the fibroblasts. These cells release pre-stages to the extracellular space and there the material is oriented into fibrils.The cells and fibrils are embedded in a matrix of a slimy ground substance. This substance binds water and determines and/or controls the turgor of the skin, its thickness, moisture, and vascularity, and even the condition of the epidermis, hairs, nails, and glands. A slight disturbance of the

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